Monogenic obesity extremely severe obesity in the absence of developmental delays syndromic obesity clinically obese subjects additionally distinguished by mental retardation dysmorphic features and organ-specific developmental abnormalities and. An endophenotype must be heritable.
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Obesity is commonly classified into subgroups depending on suspected etiology.
. It does not make sense An endophenotype must co-segregate with illness within families. Why we cannot use state-dependent endophenotype. This is a debatable criterion. The Genetic Etiology of Obesity.
An endophenotype must not be state-dependent ie manifests whether illness is active or in remission.
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